Optimasi Penambahan HPMC dan PEG 400 Sediaan Serum Gel Tabir Surya Ekstrak Artocarpus altilis Dengan Metode Simplex Lattice Design (SLD)

Oleh :
Luthfi Umi Ramadhani - V3723033 - Sekolah Vokasi

Indonesia’s tropical climate, with high UV exposure, can cause skin damage, making effective sunscreen essential. Breadfruit leaves contain flavonoids that have the potential to absorb UV rays and can be formulated into a gel serum. This study aims to determine the effect of varying hydroxypropyl methyl cellulose (HPMC) and polyethylene glycol (PEG) 400 on physicochemical properties, to identify the optimal formulation, and to evaluate stability and efficacy based on Sun Protection Factor (SPF), % Erythema Transmission, and % Pigmentation Transmission.  A laboratory experimental study was conducted with eight formulations of HPMC (0,5-1%) and PEG 400 (10,5-11%) using a Simplex lattice design. Evaluation of physicochemical properties included viscosity, pH, spreadability, and adhesion test. Verification of the optimal formulation was performed using a One Sample t-Test, sunscreen efficacy was assessed using the Mansur method, and stability was evaluated using Paired T-Test and the Wilcoxon test. The results showed that variations in HPMC and PEG 400 concentrations significantly affected all physicochemical parameters. The optimal formula was obtained at 0,796 HPMC and 10,704 PEG 400 with a desirability of 0,803 and was deemed valid, yielding an SPF of 33,02 (ultra), %TE of 0,10% (sunblock), and %TP of 0,22% (sunblock). Viscosity, adhesion, SPF, %TE, and %TP were unstable, while pH and spreadability were stable. It was concluded that the gel serum formulation is effective as a sunscreen but does not yet meet good stability criteria.