EFEK PEMBERIAN EKSTRAK ETANOL DAUN TALOK (Muntingia calabura L.) TERHADAP KADAR ASAM URAT SERUM TIKUS PUTIH (Rattus norvegicus L.) GALUR WISTAR HIPERURIKEMIA

Oleh :
Veronika Yanik Sulistyowati - M0403011 -

Jamaican cherry leaves contain quercetin that can decrease uric acid level by inhibiting xanthine oxydase activities. The aims of this research are to observe the effect of jamaican cherry leaves’ ethanolic extract towards the serum uric acid level of hyperuricemic male rats and to know the most effective dosage of jamaican cherry leaves’ ethanolic extract that can decrease the serum uric acid level of hyperuricemic male rats. Complete Randomized Design with 6 groups of treatment and 5 replications to each group of hyperuricemic white rats were used in this research. The treatments applied for those groups were: group 1 (positive control) allopurinol 5,04 mg/200 g BW/day, group II (negative control) CMC 0,1 % 6 ml/day, group III, IV, V, VI jamaican cherry leaves’ ethanolic extract of 54, 82, 122, 182 mg/200 g BW/day. All treatments were given for 7 days after establishment of hyperuricemic condition by chicken powder broth supplementation 100,8 mg/200 g BW/day for 21 days. Serum uric acid level were measured in day 0, 21, and 28. The data were analyzed by ANOVA and continued by DMRT test at significancy level of 5%. The result of this research showed that jamaican cherry leaves’ ethanolic extract decrease serum uric acid level. In the research, the most effective dosage to decrease serum uric acid level was 182 mg/200 g BW/day. Keywords : Muntingia calabura L., quercetin, uric acid, Rattus norvegicus L.