EFEK TERATOGENIK KOMBUCHA PADA TIKUS PUTIH (Rattus norvegicus L.) GALUR WISTAR

Oleh :
CAHYA SETIAWAN - M0402019 -

Kombucha is an anti-cancer. Anti-cancer constrain excessive mytosis as an alcilation agent, antimytosis,and antimetabolit. This research was sought to find out : the effect of kombucha on external and internal growth and development of wistar line mice fetus. This research used complete random planning with four treatment; that is by giving aquadest 2 ml/200 gr W (control); giving kombucha tea 1,4 ml/200 gr W (lowest dossage); 2,8 ml/200 gr W (suggested dossage); 4,2 ml/200 gr W (highest dossage), each treatment was done six times. The parameter which is measured includes eksternal parameter : the weight of the mother, the weight and length of the fetus, death and reabsorbtion of the fetus, and the morfology of the fetus; internal parameter includes : the shape of the skeleton, and the result of skeletal process of the fetus. Normal and homogeneous data will be analyzed with varian analysis (ANAVA), abnormal and heterogenous data will be analyzed with Kruskall-Wallis, then the test is continued using DMRT test with 5% significancy grade using SPSS software v.14. The result of the research shows that giving kombucha tea with various dossages does not factually effect the internal and external growth and development of mice fetus. Treatment on mice by giving kombucha during organogenesis phase is proven to be safe. Keywords : kombucha, teratogenic, rat fetus, Rattus norvegicus