STRUKTUR SEL DAN INDEKS MITOSIS SEL HEPAR DAN UTERUS TIKUS PUTIH (Rattus norvegicus L.) PASCA ORGANOGENESIS SETELAH PEMBERIAN EKSTRAK SARANG SEMUT (Myrmecodia

Oleh :
NURBETY ANNA GRAHANA - M0404010 -

ABSTRACT Myrmecodia pendens Merr. & Perry is plantation which has the function of anti-cancer. This research objection is to figure out the changes structure of hepar and uterus, and comparison index of mitotic of hepar cell and uterus cell. This research uses cluster random sampling with six group of treatment, each group gets five times repetition. The treatments given as follows : first group is control and uses 3 ml aquades; second, third, fourth, fifth, and sixth group is uses 3 ml from 0.025%, 0.050%, 0.075%, 0.100%, 0.125% of sarang semut extract. The rats are fed with Br II and tap water ad libitum. The experiment is given per oral on 7 – 17 gestation days (organogenesis phase). The zero day of pregnancy will be known if both of them are mating, and female rats show vaginal plug. The quantitive data of is analysed by one way anova and different test with DMRT. The result shows that the extract giving for the structure damage of hepar cell, so it influences mitotic index. The highest hepar cell damage happens to the group of 0,125 % dose that is 36,53% reversible characteristic and 14,62% irreversible characteristic. While the lowest to the group of 0,050 % dose that is 6,64% reversible characteristic and 6,25% irreversible characteristic. The highest index of mitotic of hepar cell happens to the group of 0,050% dose that is 93,69%, while the lowest to the group 0,125% dose that is 7,33%. Index mitotic of the highest uterus cell happens to the 0,125 % dose group that is 9,19 %. While the lowest to the group 0,025 % dose that is 7,33 %. The cell damage caused by the extract is not truly different so it can be categorated safe to consumsed by pregnant R. norvegicus. Keywords: Sarang semut extract, cell structure, mitotic index, hepar, uterus.