Abstrack
Introduction : Chronic Kidney Disease (CKD) leads to a gradual loss
of kidney function, increasing the risk of cardiovascular complications.
Inflammation, mediated by the NF-κB pathway, is a critical factor in CKD
progression. Vitamin D deficiency is common in CKD patients and may exacerbate
inflammation. This study investigates the effect of Vitamin D3 supplementation
on NF-κB levels in CKD-induced rats to explore its potential as a therapeutic
intervention.
Methods : This experimental study used a post-test only control group design
with male white rats (Rattus norvegicus). Rats were divided into three groups:
control, CKD-induced, and CKD + Vitamin D3. The study took place in August 2021
at Gadjah Mada University and Sebelas Maret University. NF-κB levels were
measured at four-week intervals. Data analysis was performed using SPSS,
including ANOVA and post-hoc tests to assess the effects of Vitamin D3 on NF-κB
levels.
Results : Significant differences in NF-κB levels were observed across the
groups. The CKD group showed a steady increase in NF-κB levels, while the CKD +
Vitamin D3 group exhibited a significant decrease. By the fourth week, NF-κB
levels in the Vitamin D3 group were substantially lower than in the CKD group,
indicating the potential anti-inflammatory effects of Vitamin D3
supplementation.
Discussion : Vitamin D3 supplementation reduced NF-κB activation
in CKD rats, suggesting that it may mitigate inflammation and slow CKD
progression. This supports the hypothesis that Vitamin D3 could offer
therapeutic benefits in managing CKD-related inflammation and atherosclerosis.
Conclusion : Vitamin D3 supplementation significantly reduced NF-κB
levels in CKD rats, offering potential for managing CKD-related inflammation.
Further research is needed to determine its clinical applicability in human CKD
patients.
Keywords : Chronic Kidney Disease, NF-κB, Vitamin D3,
Inflammation
