PENGARUH DOSIS EKSTRA ETANOL PROPOLIS GUNUNG
LAWU TERHADAP EKSPRESI MALONDIALDEHID
(MDA) DAN VEGF PADA FASE PROLIFERASI PENYEMBUHAN LUKA
TIKUS PUTIH (RATTUS NORVEGICUS) MODEL LUKA JARINGAN GRANULASI
Muhammad Apri Rajab1, Amru Sungkar 2,
Ida Bagus Budhi Surya Adnyana 3
1General Surgery Resident, Faculty of Medicine, Universitas
Sebelas Maret/Dr. Moewardi General Hospital, Surakarta, Indonesia
2Department of Plastic surgery, Universitas Sebelas
Maret/Dr. Moewardi General Hospital, Surakarta, Indonesia
3Department of Digestive Surgery, Universitas Sebelas
Maret/Dr. Moewardi General Hospital, Surakarta, Indonesia
Abstrack
Background: Wound healing is a complex
biological process involving inflammation, proliferation, and tissue
remodeling. Oxidative stress delays healing by increasing Malondialdehyde (MDA)
expression and decreasing Vascular Endothelial Growth Factor (VEGF). Propolis
contains Caffeic Acid Phenethyl Ester (CAPE), an antioxidant and
anti-inflammatory compound that may accelerate wound healing.
Objective: To evaluate the effect of
different doses of ethanol extract of Mount Lawu propolis on MDA and VEGF
expression during the proliferative phase of wound healing in white rats
(Rattus norvegicus) with granulation tissue wounds.
Methods: An experimental post-test only
control group design was conducted on rats with granulation tissue wounds.
Subjects were divided into treatment groups receiving varying doses of propolis
extract. MDA and VEGF expressions were assessed using immunohistochemistry and
statistically analyzed.
Results: A significant decrease in MDA expression and increase in VEGF expression were observed in certain propolis dose groups compared to control (p<0>
Conclusion: Ethanol extract of Mount Lawu
propolis reduces oxidative stress (MDA) and enhances angiogenesis (VEGF) during
the proliferative wound healing phase. Propolis may serve as a natural adjuvant
therapy to accelerate healing of granulation tissue wounds.
Keywords: Propolis, MDA, VEGF, wound
healing, white rats, oxidative stress
