Hubungan Residu Lambung dengan Gangguan Fungsi Jantung pada Neonatus Berisiko Sepsis

Oleh :
Maria Galuh Kamenyangan Sari - S 50070801 - Pascasarjana

Background: Neonatal sepsis with heart dysfunction lacking regarded as main pathology of sepsis. The death rate doubly in sepsis neonatal accompanied cardiovascular dysfunction. The myocardial dysfunction defined as diagnostic criteria for severe sepsis in adult. The occurrence of sphlancnic and mesenteric hypo-perfusion impact disorder of digestive system which manifest as gastric residue. Objective: to analyze the relationship between gastric residue and heart dysfunction among neonates at risk of sepsis Method: This cross-sectional study was conducted in January 2011 – October 2011 to neonates suspected sepsis who were hospitalized at Neonatal-HCU Moewardi General Hospital Surakarta. Sample was selected by quota sampling. Sepsis was assessed by clinical major-minor criteria. Gastric residue was defined when the volume of gastric aspiration 4 hours after feeding reached = 20% for 2 days. Heart dysfunction was measured using two-dimensional Doppler echocardiography. Chi square test was performed to analyze this data using SPSS 17.0. Results: Among 48 septic risk neonates, we found 27(56.3%) manifested as gastric residue, 25(64.1%) having heart dysfunction which 17 (70.8%) is the systolic function disorders. Impaired heart function, especially disorders of systolic function, are at risk of undergoing gastric residue significantly (OR:6.25; CI95%:1.14 – 34.29 and OR:3.40; CI95%: 1.03 – 11.26, respectively). Neonates whose gastric residue as milk are at risk of heart dysfunction compared with no gastric residue insignificantly (OR:8.00; CI95%:0.87 – 73.27). Conclusion: There was a relationship between gastric residue and heart dysfunction among neonates at risk of sepsis. The presence of gastric residue can become a marker of heart dysfunction among septic risk neonates.