ABSTRAK
Latar belakang: DM tipe 2 dengan hipertensi merupakan penyakit inflamasi kronik dan sering disertai dislipidemia yang berisiko terjadi aterosklerosis. Apolipoprotein B merupakan marker dislipidemia aterogenik dan prediktor yang lebih baik untuk risiko kardiovaskuler dibanding LDL maupun kolesterol non-HDL. Tujuan dari penelitian ini adalah untuk mengetahui apakah terdapat korelasi antara CRP dan apo B pada DM tipe 2 dengan hipertensi.
Metode: Penelitian ini merupakan kuantitatif non eksperimental dengan rancangan observational analytic melalui pendekatan cross sectional. Populasi penelitian sebanyak 44 pasien DM tipe 2 dengan hipertensi poliklinik penyakit dalam RS Dr.Moewardi pada bulan Maret 2015. Variabel penelitian yaitu CRP dan apo B. Pemeriksaan CRP dan apo B menggunakan metode imunoturbidimetri, Korelasi variabel dianalisis dengan korelasi Spearman. Nilai p bermakna bila < 0,05.
Hasil: Mean kadar pemeriksaan CRP yaitu 1,18 mg/dl, sedangkan apo B yaitu 110 mg/dl. Hasil analisis data didapatkan koefisien korelasi sebesar 0,75, p < 0,05.
Kesimpulan: Terdapat korelasi antara CRP dan apo B pada DM tipe 2 dengan hipertensi.
Kata kunci: C-reactive protein, apolipoprotein B, diabetes melitus tipe 2, hipertensi
ABSTRACT
Background: Type 2 DM with hypertension is a chronic inflammatory disease and often occurs with dyslipidemia as a risk of atherosclerosis. Apolipoprotein B is a marker of atherogenic dyslipidemia and a better predictor of cardiovascular risk than LDL and non-HDL cholesterol. The aim of this study is to determine whether there is a correlation between CRP and apo B in type 2 DM with hypertension.
Method: This study was a quantitative non-experimental observational analytic design through a cross-sectional approach. Population of this study were 44 type 2 DM with hypertension, internal medicine outpatients unit, Dr.Moewardi hospital in March 2015. Variable research was CRP and apo B. CRP and apo B were measured with immunoturbidimetry method. Correlation variables were analyzed with the Spearman correlation, with p < 0,05 considered as statistically significant.
Results: The mean level of the CRP is 1,18 mg/dl and apo B is 110 mg/dl. The correlation coefficient between CRP and apo B is 0,75 with p < 0,05.
Conclusions: There is a correlation between CRP and apo B in type 2 DM with hypertension.
Keyword: C-reactive protein, apolipoprotein B, type 2 diabetes mellitus, hypertension
