ABSTRACT

EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION AND UPPER LIMB EXERCISE ON LEAN BODY MASS, VEP1, AND BODE INDEX IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Daniel Pratama, A. Farih Raharjo, Ana Rima Setijadi, Jatu Aphridasari, Harsini, Hendrastutik Apriningsih, Brigitta Devi Anindita Hapsari

Departement of Pulmonology and Respiratory Medicine Medical Faculty of Sebelas Maret University/Dr. Moewardi General Hospital Surakarta

Sebelas Maret University Hospital Surakarta

Background: Chronic obstructive pulmonary disease is a disease that affects lung and extrapulmonary organ function with decreased VEP1/KVP < 0>

Methods: Clinical research with a quasi pretest-post-test control group design on pulmonary patients diagnosed with COPD at the RS UNS policlinic from January 2024 to March 2024 by consecutive sampling. The subjects were divided into treatment group with combination of creatine monohydrate supplementation and upper limb exercise, group with creatine monohydrate only and control group. All three groups adhered to standard pharmacological inhaler therapy in accordance with GOLD 2023 guidelines, along with the non-pharmacological intervention of pursed lip breathing. Lean body mass, VEP1% and quality of life at the time before and after treatment in the 3 groups.

Results: A total of 30 subjects of COPD patients who were treated participated in this study. Lean body mass variables in the creatine supplementation and upper limb exercise groups with a value of p = 0.002 which means there is a significant difference between groups. Meanwhile, VEP1% and BODE Index obtained p>0.05 which means there is no significant difference.

Conclusion: Creatine monohydrate supplementation and upper limb exercise increased lean body mass in COPD patients and improve VEP1, quality of life (BODE Index) but not significant in statistic.

Keywords: suplementasi kreatinin monohidrat, latihan ekstremitas atas, PPOK, VEP1, Indeks BODE.