Background Back: One of the genetic factors which is important in the risk of transforming endometriosis malignancies into cancer ovaries, also known as endometriosis-associated ovarian cancer (EAOC) is a mutation in the BRAF gene. This study aims to find out the relationship BRAF gene expression in endometriosis against malignant transformation Endometriosis becomes ovarian cancer or EAOC.

Method: Research It uses a retrospective case control approach. A total of 60 research subjects who have met the inclusion and exclusion criteria are carried out immunohistochemical examination (CPI) to see BRAF gene expression and histopathological examination to see the microscopic picture of cells and degree and nature of its malignancy, which is classified as endometriosis typical, atypical endometriosis and endometrioid and clear ovarian cancer cell. The data from the CPI examination and histopathology were analyzed using Univariate and bivariate statistical analysis to see the relationship between variables using SPSS 29.0 software.

Results: Yes Positive and significant correlation (r = 0.821, p<0 xss=removed istranslated="1">

Conclusion: There is a significant relationship with a positive correlation between BRAF gene expression in typical endometriosis and atypical endometriosis against transformation of endometriosis malignancy into ovarian cancer or EAOC.