UJI SITOTOKSISITAS DAN EFEK ANTIPROLIFERASI SARI Pandanus conoideus Lam. VARIETAS BUAH KUNING PADA SEL KANKER PAYUDARA T47D SECARA IN VITRO
Penulis Utama
:
Dian Indah Pratiwi
NIM / NIP
:
M0405005
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ABSTRACT
Breast cancer was the most common cancer in Indonesian woman after cervix
cancer. Many breast cancer treatment like surgery, chemotherapy, and radiotherapy
had not effectiveness result. That is caused many alternative treatment such as herbal
medicine. Yellow fruit Pandanus conoideus Lam. was one of plants that has
empirical study became anticancer agent because the lack of carotene, beta carotene
and -tocopherol. The aims of this study were to know cytotoxicity and
antiproliferative effect of yellow fruits P. conoideus Lam. on in vitro breast cancer
cell line T47D.
Direct counting method used in cytotoxicity test using haemocytometer and
tryphan blue staining. RPMI 1640 used as medium to culture cell, and treatmented
with yellow fruits P. conoideus Lam. from I Made Budi. Doubling time sampling
done at 0, 24, 48, 72 hours.
The result from cytotoxicity test showed that LC50 yellow fruits P. conoideus
Lam was 0,25 µl/ml. Doubling time test showed that yellow fruits P. conoideus Lam.
in 0,125 µl/ml can inhibit cancer grow with doubling time 1,9 times compared with
the control. The result cloclused that yellow fruit P. conoideus Lam. potent as
anticancer agent on breast cancer cell line T47D.
Key words: Yellow fruits Pandanus conoideus Lam., breast cancer cell line T47D,
cytotoxicity test, antiproliferative effect, in vitro
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Penulis Utama
:
Dian Indah Pratiwi
Penulis Tambahan
:
-
NIM / NIP
:
M0405005
Tahun
:
2009
Judul
:
UJI SITOTOKSISITAS DAN EFEK ANTIPROLIFERASI SARI Pandanus conoideus Lam. VARIETAS BUAH KUNING PADA SEL KANKER PAYUDARA T47D SECARA IN VITRO
Edisi
:
Imprint
:
Surakarta - FMIPA - 2009
Program Studi
:
S-1 Biologi
Kolasi
:
Sumber
:
Kata Kunci
:
Jenis Dokumen
:
Skripsi
ISSN
:
ISBN
:
Link DOI / Jurnal
:
-
Status
:
Public
Pembimbing
:
1. Dr. Okid Parama Astirin, M.S. 2. Dinar Sari C. W., S. Farm. Apt. M. Si
Penguji
:
Catatan Umum
:
Fakultas
:
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:
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