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Penulis Utama :
Debora Marga Pangestika
NIM / NIP :
S962102005
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</p><p class="MsoNormal" xss=removed><b><span lang="NO-BOK" xss=removed>Latar
Belakang:</span></b><span lang="NO-BOK" xss=removed> </span><i><span lang="IN" xss=removed>Autoimmune Inflammatory Rheumatic
Disease</span></i><span lang="IN" xss=removed> (AIIRD) atau reumatik autoimun merupakan kelompok
penyakit yang terdiri dari LES, Sindroma Sjogren, dan Artritis Reumatoid. Pasien
AIIRD memerlukan terapi glukokortikoid jangka panjang. Terapi glukokortikoid
memiliki<span xss=removed> </span>banyak efek samping salah
satunya <i>glucocorticoid induced</i> osteoporosis (GIOP). Sel punca mesenkimal
diharapkan sebagai terapi baru yang menjanjikan untuk mengurangi remodeling
tulang fase resorpsi penderita reumatik autoimun.</span></p>
<p class="MsoNormal" xss=removed><b><span lang="IN" xss=removed>Metode:</span></b><span lang="IN" xss=removed>
Penelitian dilakukan secara </span><i xss=removed><span lang="IN" xss=removed>randomized control trial </span></i><span lang="IN" xss=removed>(RCT) dengan <i xss=removed>pretest-<span xss=removed> </span>posttest with control group design</i>. Sampel
menggunakan pasien AIIRD yang diberikan terapi glukokortikoid dengan dosis
setara minimal prednison 5 mg dalam durasi minimal 6 bulan. Kelompok kontrol
mendapatkan terapi standar dan<span xss=removed> </span>injeksi
intramuskular NaCl 0,9% 1,5cc sedangkan kelompok perlakuan mendapat terapi<span xss=removed> </span>standar dan injeksi intramuskular sekretom
1,5 cc pada hari ke-1, hari ke-8, hari ke-15, hari<span xss=removed> </span>ke-22, hari ke-29, hari ke-36. Kadar IL-6, TNF-α, dan CTX
dinilai pada hari ke-0, hari ke-22, dan hari ke-43.</span></p>
<p class="MsoNormal" xss=removed><b><span lang="IN" xss=removed>Hasil:</span></b><span lang="IN" xss=removed> Penelitian ini melibatkan 14
subjek pada kelompok kontrol dan 14 subjek pada kelompok perlakuan. Sekretom SPM
menurunkan kadar IL-6 secara signifikan pada kelompok perlakuan (p=0,001).
Sekretom SPM menurunkan TNF-α secara signifikan pada kelompok perlakuan (p=0,001)
maupun bila dibandingkan kontrol (p=0,027). Sementara kadar CTX menunjukkan penurunan
(p=0,667) namun tidak signifikan.</span></p>
<p class="MsoNormal" xss=removed><b><span lang="IN" xss=removed>Kesimpulan:</span></b><span lang="IN" xss=removed> Sekretom sel punca mesenkimal
menurunkan kadar TNF-α maupun IL-6 secara signifikan, dan menurunkan kadar CTX tidak
signifikan pada pasien AIIRD dengan terapi glukokortikoid.</span></p>
×
Penulis Utama :
Debora Marga Pangestika
Penulis Tambahan :
1. dr. Yulyani Werdiningsih, Sp.PD, Subsp.R(K), FINASIM
NIM / NIP :
S962102005
Tahun :
2024
Judul :
Pengaruh Sekrektom Sel Punca Mesenikmal Terhadap Remodeling Tulang Fase Resopsri Penderita Reumatik Autoimun
Edisi :
Imprint :
Surakarta - Fak. Kedokteran - 2024
Program Studi :
PPDS Ilmu Penyakit Dalam
Kolasi :
Sumber :
Kata Kunci :
Sekretom, GIOP, glukokortikoid, kepadatan tulang, IL-6, CTX, TNF-?
Jenis Dokumen :
Tesis
ISSN :
ISBN :
Link DOI / Jurnal :
http://-
Link DOI :
http://-
Status :
Public
Pembimbing :
1. dr. Yulyani Werdiningsih, Sp.PD, Subsp.R(K), FINASIM
Penguji :
1. dr. Aritantri Darmayani, M.Sc, Sp.PD, K-GEH, FINASIM
Catatan Umum :
Belum ada Link Jurnal, mohon segera update link jurnal
Fakultas :
Fak. Kedokteran
×
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