| Penulis Utama |
: |
Sheila Savitri |
| NIM / NIP |
: |
S972108007 |
×
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</p><p class="MsoNormal" xss=removed><b><span xss=removed>Pendahuluan</span></b><span xss=removed>: <a name="_Hlk183111594">Kanker
ovarium merupakan jenis keganasan ginekologi dengan angka morbiditas dan
mortalitas yang semakin meningkat di negara berkembang seperti Indonesia. Salah
satu penyebabnya adalah pasien yang tidak merespon terhadap rangkaian terapi
standard.</a><a name="_Hlk183110963"><span xss=removed> </span></a><a name="_Hlk183111876"><span xss=removed><span xss=removed>Pasien dengan respon buruk terhadap terapi
standard harus menerima tambahan regimen lain. Saat ini penanda yang dapat
digunakan untuk memprediksi respon terapi secara lebih dini masih berbasis
biomolekuler, sehingga sulit diaplikasikan di daerah dengan sumber daya
terbatas.</span></span></a></span></p>
<span xss=removed></span><span xss=removed></span><span xss=removed></span>
<p class="MsoNormal" xss=removed><b><span xss=removed>Tujuan</span></b><span xss=removed>: Mengetahui peran parameter
klinis, laboratorium, dan karakteristik tumor sebagai prediktor respon terapi
pasien kanker ovarium epitel.</span></p>
<p class="MsoNormal" xss=removed><b><span xss=removed>Metode</span></b><span xss=removed>: Penelitian ini merupakan
penelitian <i>cohort </i>retrospektif terhadap 1048 pasien kanker ovarium
epitel di RSUD Dr. Moewardi Surakarta pada periode September 2019 – September
2023 yang telah menjalani terapi standard dan evaluasi respon terapi
menggunakan kriteria <span xss=removed>RECIST versi 1.1. Dilakukan
penilaian terhadap parameter klinis (usia, paritas, ascites), laboratorium
(kadar hemoglobin, nilai SII, nilai PT, kadar albumin, parameter fungsi liver
dan fungsi ginjal, kadar CA 125), dan karakteristik tumor (stadium, subtipe
histologi, dan lokasi tumor) untuk mengetahui perannya sebagai prediktor respon
terapi pasien kanker ovarium epitel.</span></span></p>
<p class="MsoNormal" xss=removed><b><span xss=removed>Hasil</span></b><span xss=removed>: Sebanyak 383 pasien (36,5%)
kanker ovarium dengan respon terapi buruk dan 665 pasien (63,5%) dengan respon
terapi baik. Adanya ascites (RR = 1,491; IK 95% 1,106 – 2,011; <i>p </i>=
0,009), kadar albumin pra terapi ≤ 3,0 g/dL (RR = 2,487; IK 95% 1,859 – 3,326; <i>p
</i>< 0 xss=removed>p </i><
0 xss=removed>p = </i>0,013),
dan keterlibatan ovarium bilateral (RR = 1,806; IK 95% 1,303 – 2,504; <i>p </i><
0></p>
<b><span xss=removed>Simpulan</span></b><span xss=removed>: Ascites, kadar
albumin pra terapi ≤ 3,0 g/dL, stadium lanjut, subtipe serosa, dan keterlibatan
ovarium bilateral dapat digunakan sebagai prediktor respon terapi pasien kanker
ovarium epitel.</span>
×
| Penulis Utama |
: |
Sheila Savitri |
| Penulis Tambahan |
: |
- |
| NIM / NIP |
: |
S972108007 |
| Tahun |
: |
2024 |
| Judul |
: |
Peran Parameter Klinis, Laboratorium, dan Karakteristik Tumor sebagai Prediktor Respon Terapi Pasien Kanker Ovarium Epitel |
| Edisi |
: |
|
| Imprint |
: |
Surakarta - Fak. Kedokteran - 2024 |
| Program Studi |
: |
PPDS Patologi Klinik |
| Kolasi |
: |
|
| Sumber |
: |
|
| Kata Kunci |
: |
kanker ovarium epitel, respon terapi, ascites, albumin, stadium |
| Jenis Dokumen |
: |
Tesis |
| ISSN |
: |
|
| ISBN |
: |
|
| Link DOI / Jurnal |
: |
- |
| Status |
: |
Public |
| Pembimbing |
: |
1. dr. Dian Ariningrum, M.Kes, Sp.PK, Subsp. N.R.(K)
2. dr. Laily Shofiyah, M.Kes, Sp.PK
|
| Penguji |
: |
1. dr. Amiroh Kurniati, M.Kes, Sp.PK, Subsp. I.K.(K)
2. Prof. Dr. JB. Suparyatmo, dr., Sp.PK, Subsp. H.K.(K)
3. Dr. dr. Heru Priyanto, Sp.OG(K)-Onk
|
| Catatan Umum |
: |
|
| Fakultas |
: |
Fak. Kedokteran |
×
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