Pengaruh Ekstrak Buah Jambu Biji Merah (Psidium guajava L.) Terhadap Kadar Trigliserida Pada Tikus Wistar Model Sindrom Metabolik

Penulis Utama : Anjani I'anatul Haq
NIM / NIP : G0021029
× <h1><b><span xss=removed>ABSTRAK</span></b><b><i><span xss=removed><o></o></span></i></b></h1><h1 align="justify" xss=removed><span xss=removed>Anjani I’anatul Haq, G0021029, 2024. Pengaruh Ekstrak Buah Jambu Biji Merah </span><i><span xss=removed>(Psidium guajava L.)</span></i><span xss=removed> </span><span xss=removed>t</span><span xss=removed>erhadap Kadar Trigliserida </span><span xss=removed>p</span><span xss=removed>ada Tikus Wistar Model Sindrom Metabolik. Skripsi. Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta. </span><span xss=removed><o></o></span></h1><p class="MsoNormal" xss=removed><b><span xss=removed>Pendahuluan:</span></b><span xss=removed> </span><span xss=removed>Sindrom metabolik merupakan penyakit gabungan kelainan metabolik yang mencakup hiperglikemia, dislipidemia, hipertensi, serta obesitas. Kelainan metabolik ini mampu menjadi faktor resiko diabetes melitus tipe 2 dan penyakit kardiovaskular. </span><i><span xss=removed>Psidium guajava L.</span></i><span xss=removed> diduga memiliki potensi memberikan efek perbaikan pada pasien yang menderita sindrom metabolik.  Tujuan dari dilakukannya penelitian ini adalah untuk mengetahui adakah pengaruh dari pemberian ekstrak buah jambu biji merah (</span><i><span xss=removed>Psidium guajava L.)</span></i><span xss=removed> terhadap kadar trigliserida pada tikus Wistar </span><i><span xss=removed>(Rattus norvegicus)</span></i><span xss=removed> model sindrom</span><span xss=removed> </span><span xss=removed>metabolik.</span><span xss=removed><o></o></span></p><p class="MsoNormal" xss=removed><b><span xss=removed>Metode:</span></b><span xss=removed> </span><span xss=removed>Penelitian ini merupakan penelitian eksperimen laboratorium dengan desain pretest dan posttest pada kelompok kontrol. Sampel terdiri dari 30 ekor tikus Wistar jantan, yang dibagi menjadi lima kelompok: K1 sebagai kontrol negatif, K2 sebagai kontrol positif, serta K3, K4, dan K5 sebagai kelompok sindrom metabolik yang diberi ekstrak </span><i><span xss=removed>Psidium guajava L.</span></i><span xss=removed> dengan dosis berurutan yaitu </span><span xss=removed>1,62</span><span xss=removed> mg/200gBB/hari, </span><span xss=removed>3,24</span><span xss=removed> mg/200gBB/hari, dan </span><span xss=removed>6,48</span><span xss=removed> mg/200gBB/hari. Kadar trigliserida pada tikus diukur pada hari ke-8, 36, dan 64. Data yang dimiliki kemudian dianalisis menggunakan uji normalitas </span><i><span xss=removed>Shapiro-Wilk</span></i><span xss=removed>, uji homogenitas </span><i><span xss=removed>Levene,</span></i><span xss=removed> uji </span><i><span xss=removed>one way ANOVA,</span></i><span xss=removed> uji </span><i><span xss=removed>post-hoc Tukey HSD,</span></i><span xss=removed> uji T berpasangan, dan uji korelasi </span><i><span xss=removed>Pearson.</span></i><span xss=removed><o></o></span></p><p class="MsoNormal" xss=removed><b><span xss=removed>Hasil:</span></b><span xss=removed> </span><span xss=removed>Pemberian ekstrak </span><i><span xss=removed>Psidium guajava L.,</span></i><span xss=removed> menghasilkan kadar trigliserida tertinggi pada kelompok K3 dan kadar terendah pada kelompok K5. Berdasarkan analisis statistik, perbedaan signifikan (p < 0><i><span xss=removed>Pearson</span></i><span xss=removed> menunjukkan bahwa dosis </span><i><span xss=removed>Psidium guajava L.</span></i><span xss=removed> memiliki hubungan yang sangat kuat dengan kadar trigliserida.</span><span xss=removed><o></o></span></p><p class="MsoNormal" xss=removed><b><span xss=removed>Simpulan: </span></b><span xss=removed>Pemberian ekstrak </span><i><span xss=removed>Psidium guajava L.</span></i><span xss=removed> secara signifikan dapat menurunkan kadar trigliserida, dengan variasi dosis </span><span xss=removed>1,62</span><span xss=removed> mg/200gBB, </span><span xss=removed>3,24</span><span xss=removed> mg/200gBB, dan </span><span xss=removed>6,48 </span><span xss=removed>mg/200gBB yang ketiganya menunjukkan efek penurunan trigliserida secara signifikan. Penelitian ini menunjukkan bahwa dosis </span><span xss=removed>6,48</span><span xss=removed> mg/200gBB terbukti paling efektif dalam menurunkan kadar trigliserida.</span><span xss=removed><o></o></span></p><p class="MsoNormal" xss=removed><b><span xss=removed>Kata Kunci: </span></b><i><span xss=removed>Psidium guajava L.,</span></i><span xss=removed> Trigliserida, Sindrom Metabolik</span><span xss=removed><o></o></span></p><p class="MsoNormal"><b><span xss=removed> </span></b></p><h1><b><i><span xss=removed>ABSTRACT</span></i></b><b><i><span xss=removed><o></o></span></i></b></h1><p class="MsoNormal"><i><span xss=removed>Anjani I’anatul Haq, G0021029, 2024. The Effect of Red Guava Extract (Psidium guajava L.) on Triglyceride Levels in Wistar Rats of Metabolic Syndrome Model. Mini-Thesis. Faculty of Medicine, Universitas Sebelas Maret, Surakarta.</span></i><i><span xss=removed><o></o></span></i></p><p class="MsoNormal"><b><i><span xss=removed>Introduction:</span></i></b><i><span xss=removed> Metabolic syndrome is a combination of metabolic disorders that include hyperglycemia, dyslipidemia, hypertension, and obesity. These metabolic disorders can be risk factors for type 2 diabetes mellitus and cardiovascular disease. Psidium guajava L. is thought to have the potential to provide an improvement effect on patients suffering from metabolic syndrome. This study aims to determine the effect of administering red guava fruit extract (Psidium guajava L.) on triglyceride levels in Wistar rats (Rattus norvegicus) as a metabolic syndrome model.</span></i><i><span xss=removed><o></o></span></i></p><p class="MsoNormal"><b><i><span xss=removed>Method:</span></i></b><i><span xss=removed> </span></i><i><span xss=removed>This study was a laboratory experimental study with a pretest and posttest design in the control group. The sample consisted of 30 male Wistar rats, which were divided into five groups: K1 as a negative control, K2 as a positive control, and K3, K4, and K5 as metabolic syndrome groups given Psidium guajava L. extract with sequential doses of </span></i><i><span xss=removed>1,62</span></i><i><span xss=removed> mg/200gBW/day, </span></i><i><span xss=removed>3,24</span></i><i><span xss=removed> mg/200gBW/day, and </span></i><i><span xss=removed>6,48</span></i><i><span xss=removed> mg/200gBW/day. Triglyceride levels in rats were measured on days 8, 36, and 64. The data were then analyzed using the Shapiro-Wilk normality test, Levene's homogeneity test, one-way ANOVA test, Tukey HSD post-hoc test, paired T test, and Pearson correlation test.</span></i><i><span xss=removed><o></o></span></i></p><p class="MsoNormal"><b><i><span xss=removed>Result:</span></i></b><i><span xss=removed> Giving of</span></i><i><span xss=removed> Psidium guajava L. extract resulted in the highest triglyceride levels in group K3 and the lowest levels in group K5. Based on statistical analysis, significant differences (p < 0></i><i><span xss=removed><o></o></span></i></p><p class="MsoNormal" xss=removed><b><i><span xss=removed>Conclusion: </span></i></b><i><span xss=removed>Giving of Psidium guajava L. extract can significantly reduce triglyceride levels, with dose variations of </span></i><i><span xss=removed>1,62</span></i><i><span xss=removed> mg/200gBW, </span></i><i><span xss=removed>3,24</span></i><i><span xss=removed> mg/200gBW, and </span></i><i><span xss=removed>6,48</span></i><i><span xss=removed> mg/200gBW, all three of which showed a significant effect of reducing triglycerides. In this study, the dose of </span></i><i><span xss=removed>6,48</span></i><i><span xss=removed> mg/200gBW proved to be the most effective in reducing triglyceride levels.</span></i><i><span xss=removed><o></o></span></i></p><p class="MsoNormal"><b><i><span xss=removed>Keywords: </span></i></b><i><span xss=removed>Psidium guajava L., Triglyceride, Metabolic Syndrome</span></i></p>
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Penulis Utama : Anjani I'anatul Haq
Penulis Tambahan : -
NIM / NIP : G0021029
Tahun : 2024
Judul : Pengaruh Ekstrak Buah Jambu Biji Merah (Psidium guajava L.) Terhadap Kadar Trigliserida Pada Tikus Wistar Model Sindrom Metabolik
Edisi :
Imprint : Surakarta - Fak. Kedokteran - 2024
Program Studi : S-1 Pendidikan Dokter
Kolasi :
Sumber :
Kata Kunci : Kata Kunci: Psidium guajava L., Trigliserida, Sindrom MetabolikKeywords: Psidium guajava L., Triglyceride, Metabolic Syndrome
Jenis Dokumen : Skripsi
ISSN :
ISBN :
Link DOI / Jurnal : -
Status : Public
Pembimbing : 1. Prof. Dr. Ida Nurwati, dr., M.Kes., Sp.Ak
2. Khesara Sastrin Prasita Negara, drh., M.Sc.
Penguji : 1. Dr. Veronika Ika Budiastuti, dr., M. Pd
Catatan Umum :
Fakultas : Fak. Kedokteran
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