Nanostructured Lipid Carriers (NLCs) as oral cancer drug delivery are subject to interference in the gastrointestinal system. Extreme pH conditions in the stomach and intestines can destabilize NLCs. Chitosan can protect from degradation and slow the diffusion of curcumin. The material needs to be modified again to improve its selectivity. Folic acid receptor content, which is generally overexpressed in cancer cells, is utilized as a targeting agent. Chitosan conjugated with folic acid as a coating for NLCs can suppress the release of curcumin in the gastrointestinal tract while enhancing its therapeutic properties. Chitosan was isolated from the gold snail shell through the stages of deproteination, demineralization, and deacetylation. Chitosan (55.45% yield) was conjugated with folic acid (CS-FA) through a coupling reaction. Both chitosan and CS-FA materials were coated on curcumin-loaded NLCs (Cur@NLCs) in a ratio of 1:10. The Cur@NLCs material showed a decrease in potential zeta value to -41.6 mV after chitosan coating and was in a stable potential zeta value. The CS-FA coated material conducted a release study in 0.1 N HCl media pH 1.2 showed a release of 4.8% then in phosphate buffer (PBS) pH 7.4 of 31.06% (7^th h) and increased to 83.65% (72^nd h). Release values reaching 99.13% (72^nd h) were shown when entering PBS pH 6.8 media at the 7^th hour. The coating modification increased the toxicity of curcumin to 12.87 µg/mL (T-47D; 24 h). This indicates that this modification can reduce the release of the drug and facilitate its entry into cancer cells.