ABSTRAK Pokok permasalahan pada penelitian ini adalah banyak faktor yang dapat mempengaruhi prestasi belajar mahasiswa pada semester pendek mata kuliah keperawatan anak II termasuk di dalamnya adalah faktor minat mengikuti semester pendek dan motivasi belajar. Penelitian ini bertujuan untuk mengetahui hubungan minat dan motivasi belajar dengan prestasi belajar semester pendek mata kuliah keperawatan anak II di STIKES Muhammadiyah Lamongan tahun akademik 2009/2010. Penelitian ini merupakan penelitian korelasional. Populasi penelitian adalah mahasiswa yang mengikuti semester pendek Prodi S1 Keperawatan semester VIII STIKES Muhammadiyah Lamongan tahun ajaran 2009/2010 yang berjumlah 54 orang, dengan simple random sampling diperoleh 48 responden. Variabel bebas terdiri dari minat (X1) dan motivasi belajar (X2). Variabel terikat adalah prestasi belajar semester pendek. Pengukuran variabel menggunakan kuesioner dan lembar nilai semester pendek mata kuliah keperawatan anak II , kemudian dianalisa dengan menggunakan metode regresi linier berganda. Berdasarkan hasil analisis diketahui minat memiliki nilai koefisien regresi standarized sebesar 0.001 dengan nilai t sebesar 0,008 yang berarti memiliki hubungan yang signifikan terhadap prestasi belajar semester pendek dan memiliki kuat pengaruh relatif sebesar 0,03%. Motivasi belajar koefisien regresi standarized sebesar 1,009 dengan nilai t sebesar 13,378 yang berarti memiliki hubungan yang signifikan terhadap prestasi belajar semester pendek dan memiliki kuat pengaruh relatif sebesar 82,7%. Hasil analisis tersebut menunjukkan bahwa minat dan motivasi belajar secara terpisah maupun bersama-sama memiliki hubungan positif terhadap prestasi belajar semester pendek mahasiswa semester VIII Prodi S1 Keperawatan STIKES Muhammadiyah Lamongan. Kata Kunci : Minat, Motivasi Belajar, Prestasi belajar semester pendek ABSTRAK The rationale of this research is that are a number of factors that can affect students’in Short-term semester learning achievement in Child Nursing II course. These include students’interest to take the Short-term semester and the their learning motivation. This research aims at finding out the correlation between students’interest and motivation and students’ Short-term semester learning achievement in in Child Nursing II at STIKes Muhammadiyah Lamongan of 2009/2010 Academic Year. The research is a correlation study. The Population of this research are 54 students taking Short-term semester courses at Nursing Study Program STIKes Muhammadiyah Lamongan in 2009/2010 academic year. Of this figure, 48 student were randomly selected as respondents. The independent variables of this research constist (X1) and learning motivation (X2) while its dependent variable is students’learning achievement in taking Short-semester courses. The data about those variables were obtained with questionnaire and score sheet oe Short-term semester of Child Nursing II. The research data were analyzed using multiple liniar regression method. The results of data analysis indicate that 1) the score of standardized regression coefficience of interest variable is 0,001 whit t-score = 0,008 whith means taht there is a significant correlation between students’interest in taking Short-term semester course and their learning achievement and the relative affect is 0,03% and 2) the score of standardized regression coefficience of motivation variable is 1,009 with t-score =13,378 which means that there is a significant correlationbetween students’interest in taking Short-term semester course and their learning achievement and the relative affect is 82,7%. These results imply tahat the variables of interest and motivation separately or simultaneously have a significant correlation with students’learning achievement. Key words : Interest, learning motivation, learning achievement, short-term course.