Efek ekstrak kulit terong ungu terhadap kadar LDL dan HDL darah tikus putih
Penulis Utama
:
Refilia Rukmanasari
NIM / NIP
:
G0007137
×ABSTRACT
The Objective : The objective of this research is to know the effects of eggplant peel extract (Solanum melongena L.) to the LDL and HDL blood level in Wistar rats.
The Methods : The research was performed as experimental pre and post test with control group design. This research use 30 male Wistar rats, the weight about 200 grams, and about 2 months old. The Wistar rats divided into 5 groups using purposive random sampling tecnique. The first group as negative control group, the second group as positive control group, the third, the fourth, and the fifth groups are eggplant (Solanum melongena L.) peel extract group first dose, second dose, and third dose. All rats fed hypercholesterolemics feed contains 3 gram/200 gram weigh/day lard and 2 gram/200 gram weight/day duck egg yolk, the second group added Cholvastin powder 0,5 mg/200 gram weight/day, the third, the fourth, and the fifth groups are added eggplant peel extract 25 mg/200 gram weight/day, 50 mg/200 gram weight/day, and 100 mg/200 gram weight/day. Total periods of this research was 23 days. The pre test and post test delta mean of LDL blood level analized by ANOVA and HDL blood level analized by Kruskal-Wallis.
The result : The result of this research shows value of p=0,000 (p<0,05) that means there was significant pre test and post test delta mean LDL blood level difference among the groups and p=0,157 (p>0,05) shows that there was not significant pre test and post test delta mean HDL blood level difference among the groups.
The conclusion: The research concluded that eggplant (Solanum melongena L.) peel extract significantly lowering the LDL blood level in Wistar rats but significantly doesn’t affect the HDL blood level in Wistar rats.
ABSTRAK
Refilia Rukmanasari, G0007137, 2010. Efek Ekstrak Kulit Terong Ungu (Solanum melongena L.) terhadap Kadar LDL dan HDL Darah Tikus Putih. Skripsi. Surakarta. Fakultas Kedokteran UNS. Agustus 2010.
Tujuan penelitian untuk mengetahui adakah pengaruh pemberian ekstrak kulit terong ungu (Solanum melongena L.) terhadap kadar LDL dan HDL darah tikus putih.
Metode penelitian yaitu eksperimental laboratorik, rancangan penelitian pre and post test with control group design. Subjek penelitian 30 ekor tikus putih jantan, strain Wistar, berat badan ± 200 gram, berumur ± 2 bulan. Tikus putih dibagi menjadi 5 kelompok dengan teknik Purposive Random Sampling. Kelompok I (kontrol negatif), kelompok II (kontrol positif), kelompok III, IV, dan V (kelompok ekstrak kulit terong ungu dosis I, II, dan III). Semua kelompok diberi pakan lemak babi 3 gram/200 gram BB/hari dan kuning telur bebek 2 gram/200 gram BB/hari, kelompok II ditambah serbuk cholvastin 0,5 mg/200 gram BB/hari, kelompok III, IV, dan V ditambah ekstrak kulit terong ungu berturut-turut 25 mg/200 gram BB/hari, 50 mg/200 gram BB/hari, dan 100 mg/200 gram BB/hari. Penelitian dilakukan selama 23 hari. Analisis data menggunakan uji ANOVA untuk menganalisis kadar LDL dan uji Kruskal-Wallis untuk kadar HDL darah tikus putih.
Hasil penelitian menunjukkan nilai p=0,000 (p<0,05) sehingga terdapat perbedaan kadar LDL darah tikus putih antar kelompok yang signifikan, sedangkan kadar HDL darah tikus putih antar kelompok didapatkan hasil p=0,157 (p>0,05) menunjukkan tidak adanya perbedaan yang signifikan.
Simpulan penelitian yaitu ekstrak kulit terong ungu (Solanum melongena L.) berpengaruh terhadap penurunan kadar LDL dan tidak berpengaruh terhadap peningkatan kadar HDL darah tikus putih.
×
Penulis Utama
:
Refilia Rukmanasari
Penulis Tambahan
:
-
NIM / NIP
:
G0007137
Tahun
:
2010
Judul
:
Efek ekstrak kulit terong ungu terhadap kadar LDL dan HDL darah tikus putih
Edisi
:
Imprint
:
Surakarta - F.Kedokteran - 2010
Program Studi
:
S-1 Pendidikan Dokter
Kolasi
:
Sumber
:
UNS- F.Kedokteran Jur. Ilmu Kedokteran -G.0007137-2010
