ABSTRAKLatar Belakang dan Tujuan: Angka kejadian asfiksia sedang Di RSUDKaranganyar sebesar 758 jiwa (53,8%). Tujuan untuk mempelajari dan memahamiasuhan kebidanan pada bayi Ny.S dengan asfiksia sedang di RSUD Karanganyarsecara komprehensif.Metode: Observasional deskriptif dengan pendekatan studi kasus. Subjekpenelitian bayi Ny.S dengan asfiksia sedang. Cara pengambilan data melaluiwawancara, observasi langsung dan studi dokumen rekam medik. Analisis datasecara deskriptif berdasar 7 langkah Varney dan SOAP.Hasil: Bayi Ny.S lahir spontan dengan induksi, air ketuban keruh, bayi tidakmenangis spontan, sianosis perifer, napas lambat dan tidak teratur. APGAR score6/7/8. Diberikan asuhan resusitasi HAIKAL, Oksigen head box 4 liter/menit, dancefotaxim 125 mg/12jam. Setelah dilakukan perawatan, keadaan bayi membaik,menangis kuat, napas teratur, dan gerak aktif.Kesimpulan: Bayi telah mendapatkan terapi dan perawatan selama 3 hari,Keadaan bayi membaik, menangis kuat, nafas teratur, dan gerak aktif. Tidakterdapat kesenjangan teori dan praktek.Kata Kunci: Asuhan kebidanan, bayi, asfiksia sedang.ABSTRACTBackground and Objective: The number of moderate asphyxia incidences at theLocal General Hospital of Karanganyar was 758 (53.8%). The objective is tostudy and understand the midwifery care on the infant of Mrs.S with moderateasphyxia at the Local General Hospital of Karanganyar comprehensively.Method: This research used the observational descriptive research method withthe case study approach. The subject of research was the infant of Mrs.S withmoderate asphyxia. The data of research were collected through in-depthinterview, direct observation, and content analysis of medical record. The data ofresearch were descriptively analyzed by using Varney’s Seven Steps and SOAP.Result: The infant of Mrs.S was spontaneously born with induction, the amnioticfluid was turbid, the infant did not cry loudly, cyanosis perifer, and the breath wasslow and irregular. The APGAR score was 6/7/8. The infant was given HAIKALresuscitation, oxygen head box 4 liters/minute, and cefotaxim 125 mg/12hours.The nutrition was fulfilled. Following the treatment, the infant had goodgeneral conditions, regular breath, and active motions and cried loudly.Conclusion: Following three days of therapy and supportive treatment, the infanthad good condition, regular breath, active motion, and cried loudly. Not gap wasfound between the theory and the practice.Keywords: Midwifery care, infant, moderate asphyxia