ABSTRAKLatar Belakang: Kota Surakarta merupakan prevalensi tertinggi kedua kasuskanker payudara sebesar 678 kasus di Jawa Tengah. Pemeriksaan Payudara Sendiri(SADARI) merupakan deteksi dini kanker payudara. Studi pendahuluan didapatkansiswi SMA Islam Diponegoro Surakarta belum mengetahui tentang pemeriksaanpayudara sendiri. Tujuan penelitian ini untuk mengetahui pengaruh pendidikankesehatan terhadap praktik SADARI.Metode: Penelitian ini menggunakan metode Eksperimen semu dengan pendekatanpretest-postest with control group design. Subjek penelitian adalah siswi kelas Xdan XI di SMA Islam Diponegoro yang diambil dengan teknik random sampling.Jumlah sampel sebanyak 46 responden yang memenuhi kriteria retriksi, dengan 22responden sebagai kelompok eksperimen dan 24 lainnya sebagai kelompok kontrol.Analisis data menggunakan Mann Whitney.Hasil: Rata-rata nilai pretest dan postets keterampilan pemeriksaan payudarasendiri (SADARI) pada kelompok kontrol sebesar 3,08 dan 3,17, sedangkan padakelompok eksperimen sebesar 3,45 dan 24,77. Hasil analisis Uji Mann Whitneymenunjukkan p = 0,000.Simpulan: Ada pengaruh pendidikan kesehatan terhadap praktik SADARI padasiswi SMA Islam Diponegoro SurakartaKata kunci : Pendidikan Kesehatan, Pemeriksaan Payudara Sendiri(SADARI)ABSTRACTBackground. Breast self-examination is an early detection of breast cancer.whendone since the adolescent age, it can decrease the number of mortalities due tobreast cancer. The dissemination of information on the breast self-examinationthrough health education can improve the knowledge of breast examination, whichaffects the attitude and behavior on the breast-self examination. A preliminaryresearch shows that the female students of Islam Diponegoro Senior SecondarySchool of Surakarta did not know breast self-examination. Objective: Toinvestigate the effect of health education on the breast self-examination practice.Method: This research used the quasi experimental method with the pretest-posttestwith control group design. The samples of research were taken by using the randomsampling technique. They consisted of 46 respondents and were divided into twogroups, 22 in the experimental group and 24 in the control group. The data ofresearch were collected through observation aided with checklists. They wereanalyzed by using the Mann Whitney’s Test.Result: The pretest and posttest average scores of the breast self-examination ofthe control group were 3.08 and 3.17 respectively, meanwhile those of theexperimental group were 3.45 and 24.77. The result of the Mann Whitney’s Testshows that the p-value was 0.000.Conclusion: There was an effect of the health education on the breast selfexaminationpractice of the female students of Islam Diponegoro Senior SecondarySchool of Surakarta.Keywords: Health education, Breast self-examination