ABSTRAKLatarBelakang: Kanker serviks masih merupakan penyebab umum kematian palingsering pada keganasan di bidang ginekologi di Indonesia. Penatalaksanaan kankerserviks stadium lanjut sampai saat ini masih belum bisa memperbaiki prognosisnya.Intervensi kemoterapi dalam pengobatan kanker serviks stadium lanjut menimbulkanstres psikologis pada pasien, reaksi terhadap agen inflamasi dari daerah luka akanmenyebabkan terjadinya rangsangan pada hipotalamus-hipofisis-adrenal axis (HPAaxis)dengan dampak meningkatnya seksresi ACTH oleh hipofisis anterior yangselanjutnya korteks adrenal akan terangsang untuk mensekresi kortisol.Tujuan: Menganalisa adanya perbedaan kadar kortisol serum pada pasien kankerserviks stadium lanjut sesudah intervensi psikoterapi Cognitive Behavior Therapy(CBT) dengan terapi standar.MetodePenelitian: Jenis penelitian adalah experimental double blind non randomizedclinical trial post test group design. Dari 30 subyek penelitian, dibagi dalam 2kelompok (terapi standar tanpa CBT dan terapi standar dengan intervensi CBT) dansetiap kelompok terdiri dari 15subjek.Hasil: Nilai mean kadar kortisol pada kelompok terapi standar tanpa CBT 11,41±7,34,dan kelompok terapi standar dengan CBT 1,03±0,71. Kadar kortisol pada kelompokterapi standar tanpa CBT didapatkan nilai mean lebih tinggi (11,41±7,34) dibandingkandengan nilai mean kelompok terapi standar dengan CBT (1,03±0,71) dengan nilaip=0,00(<0,05).Kesimpulan: Terdapat perbedaan penurunan kadar kortisol serum yang signifikan padakelompok yang mendapatkan terapi standar dengan intervensi CBT. Pemberian CBTefektif menurunkan kadar kortisol serum pasien pada pasien kanker serviks stadiumlanjut yang sudah diberikan terapi standar.Kata kunci: Kortisol, CBT, Kanker serviks stadium lanjutABSTRACTBackground: Cervical cancer is the most leading cause of death in malignancy of ingynecology area in Indonesia. The management of advanced stage-cervical cancer hasnot been able to improve its prognosis currently. Chemotherapy intervention inadvanced stage-cervical cancer results in psychological stress among the patients, andreaction against inflammation agent in lesion area will result in stimulation inhypothalamus-hypophysis-adrenal axis (HPA-axis) leading to increased secretion ofACTH by anterior hypophysis and then stimulating adrenal cortex to secrete cortisol.Objective: To analyze the difference of cortisol level in advanced-stage cervical cancerpatient after cognitive behavior therapy (CBT) and standard therapy interventions.Method: This study was an experimental double blind non-randomized clinical trialpost test group design. The 30 subjects of research were divided into 2 groups (standardtherapy without CBT and standard therapy with CBT intervention) and each groupconsisted of 15 subjects.Result:The mean score of cortisol level in the standard therapy group without CBT was11.41 ± 7.34, and that with CBT was 1.03 ± 0.71. Cortisol level of the standard therapygroup without CBT was higher (11.41 ± 7.34) compared with that of group with CBT(1.03 ± 0.71) with p value = 0.00 (<0.05).Conclusion: There was a significantly different decrease in serum cortisol level in thegroup receiving standard therapy with CBT intervention. The administration of CBTeffectively lowered the serum cortisol level in the advanced stage-cervical cancerpatient who had received standard therapy.Keywords: Cortisol, CBT, advanced stage-cervical cancer.