ABSTRACT
Background: Cervical cancer is the most leading cause of death in developing countries. The women diagnosed with cervical cancer in the advance stadium, often develops extraordinary emotional stress. This can make depression and make effect to serotonin level. Psychotherapy administration can exert positive effect.
Objective: To analyze the difference of serotonin level and pain score in advanced-stage cervical cancer patient having received reality psychotherapy compared with standard therapy in Moewardi Local General Hospital of Surakarta.
Method: Experimental double blind randomized clinical trial post test group design. The 30 subjects of research were divided into 2 groups (standard therapy without reality psychotherapy and standard therapywith  reality psychotherapy) and each group consisted of 15 subjects. This research was conducted in obstetric and gynecology ward and polyclinic of dr. Moewardi Local General Hospital of Surakarta and Prodia Laboratory, from January to March 2015.
Result:The distribution of serotonin level mean value in cervical cancer patient intervention groupseemed to be upper(223.59 + 41.20), than the control group (78.22 + 30.49). From the t-test analysis, it could be seen that there was a significant difference of serotoninlevel in cervical cancer intervention group and control group with p value = 0.000 (< 0.05).The distribution of pain score level mean value in intervention group seemed to be lower (5.46 + 0.83) than in the control group  (6.00 + 1.06).From the t test analysis, it could be seen that there was not a significant difference of pain score in control group and intervention goup with p value =0.139 (>0.05).
Conclusion: There was a significantly increasing serotonin level and there was not a significantly decreasing pain score in the group receiving standard therapy with reality psychotherapy intervention. The administration of reality psychotherapy effectively upped the serotonin level in the advanced stage-cervical cancer patient.
Keywords: Serotonin, Pain score, Reality psychotherapy, Advanced stage-cervical cancer.
Abstrak
LatarBelakang:Kanker serviks merupakan penyebab kematian terbanyak di negara berkembang. Wanita yang didiagnosis kanker serviks stadium lanjut sering menderita stress emosional yang luar biasa.Stress emosional lama kelamaan akan menyebabkan depresi yang akan menurunkan kadar serotonin.Pemberian psikoterapi dapat berdampak positif.
Tujuan:Menganalisis terjadinya perbedaan kadar serotonin dan skor nyeri pasien kanker serviks stadium lanjut setelah mendapatkan psikoterapi realitas bila dibandingkan dengan terapi standart di RSUD dr Moewardi Surakarta.
Metode Penelitian:Experimental double blind randomized clinical trial post test group design. 30 subyek penelitian dibagi 2 kelompok (terapi standart tanpa psikoterapi realitas dan terapi standar denganpsikoterapi realitas) dansetiapkelompok terdiri dari 15 subjek.  Penelitian dilakukan di bangsal dan poliklinik kebidanan dan kandungan RSUD dr Moewardi Surakarta dan Laboratorium Prodia, dimulai bulan Januari – Maret 2015.
Hasil:Distribusi rerata kadar Serotonin pada kelompok pasien kanker serviks yang mendapatkan perlakuan tampak lebih tinggi (223.59 + 41.20), dibandingkan dengan kelompok kontrol  (78.22 + 30.49). Analisis uji t terbukti bahwa kadar serotonin pada kelompok perlakuan dan kelompok kontrol terdapat perbedaan yang signifikan dimana nilai p=0.00 (<0.05).Distribusi rerata skor nyeri pada kelompok perlakuan  tampak lebih rendah (5.46 + 0.83), dibandingkan dengan kelompok kontrol  (6.00 + 1.06).Analisis uji t terbukti bahwa kadar  serotoninantara kelompok perlakuan  dan kelompok kontrol  tidak terdapat perbedaan yang signifikan dimana nilai p=0.139 (>0.05).
Kesimpulan:Terdapat perbedaan kadar serotonin yang signifikan pada kelompok terapi standart dengan intervensi psikoterapi realitas. Pemberian psikoterapi realitas efektif meningkatkan kadar serotonin pada pasien kanker serviks stadium lanjut. Tidak terdapat perbedaan skor nyeri yang signifikan pada kelompok terapi standart dengan intervensi psikoterapi realitas
Kata kunci:Serotonin, Skor nyeri, Psikoterapi realitas, Kanker serviks stadium lanjut.