INTISARI
Pendahuluan: Diabetes melitus (DM) tipe 2 terjadi dislipidemia dengan karakteristik peningkatan trigliserida, jumlah small dense Low Density Lipoprotein (sdLDL), dan penurunan High Density Lipoprotein (HDL). Inflamasi, stres oksidatif pada DM tipe 2 meningkatkan sdLDL dan Asymetrical Dimethylarginine (ADMA) yang berlanjut disfungsi endotel dan aterosklerosis. Tujuan penelitian ini menganalisis korelasi antara sdLDL dan ADMA pada pasien DM tipe 2.
Metode: Desain penelitian analitik observasional dengan pendekatan cross sectional pada pasien DM tipe 2 di Poliklinik Penyakit Dalam RSUD dr Moewardi (RSDM) pada bulan September–November 2015. Jumlah sampel penelitian 41 orang. Uji korelasi sdLDL dan ADMA menggunakan uji korelasi Spearman, p<0,05 dianggap signifikan, interval kepercayaan 95%.
Hasil: Umur dengan median(persentil 25-75) 57,00(52,00-59,50) tahun, sdLDL 1,09(0,95-1,18). Rerata ADMA 0,60±0,14 μmol/L. Uji korelasi antara ADMA dan sdLDL (r=-0,099; p=0,536), tekanan darah sistolik (r=0,524; p=0,001), trigliserida (r=0,312; p=0,047).
Simpulan: Tidak didapatkan korelasi antara sdLDL dan ADMA pada pasien DM tipe 2. Penelitian lanjutan perlu dilakukan dengan mempertimbangkan faktor risiko aterosklerosis dan terapi pada pasien DM tipe 2 sehingga peran sdLDL dan ADMA sebagai marker disfungsi endotel diketahui lebih mendalam.
Keyword: DM tipe 2, sdLDL, ADMA, disfungsi endotel, aterosklerosis

ABSTRACT
Introduction: Dyslipidemia in type 2 Diabetes mellitus (DM) include the elevated triglycerides, small dense Low Density Lipoprotein (sdLDL) number, and lowering on HDL. The inflammation, oxidative stress in type 2 diabetes increase sdLDL and Asymetrical Dimethylarginine (ADMA) level to generate endothelial dysfunction and atherosclerosis. This study was conducted to find the correlation between sdLDL and ADMA in type 2 DM patients.
Methods: This analytical observational study used cross-sectional approach type 2 DM patiens in the Internal Medicine Polyclinic dr Moewardi Hospital in September-November 2015. The amount of sample was 41 people. The correlation between sdLDL and ADMA used Spearman correlation test, p <0,05 was considered significant, 95% confidence interval.
Results: The ages were median(percentile 25th- percentile 75th) 57,00(52,00-59,50), sdLDL 1,09(0.95-1,18). The mean value of ADMA were 0.60±0.14 μmol/L. The correlation test between ADMA and sdLDL (r =-0,099; p=0,536), systolic blood pressure (r=0,524; p=0,001), triglyceride (r = 0,312 ; p=0,047).
Conclusion: There was no correlation between sd LDL and ADMA in patients with type 2 DM. The further studies were needed with the considering of atherosclerosis risks and therapies in type 2 DM patients, so the role of ADMA and sdLDL as endothelial dysfunction marker will known more.
Keywords: Type 2 DM, sdLDL, ADMA, endothelial dysfunction, atherosclerosis