ABSTRAK
Latar Belakang: Kayu manis mengandung asam sinamat, sinamaldehid, flavonoid, dan polifenol yang diketahui memiliki potensi sebagai antihiperkolesterol sehingga dapat menurunkan kadar kolesterol LDL. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian seduhan kayu manis (Cinnamomum burmanii) terhadap kadar kolesterol LDLdarah pada tikus putih (Rattus norvegicus) model hiperlipidemia.
Metode Penelitian: Penelitian ini merupakan penelitian eksperimental laboratorik dengan rancangan the post test only controlled group design. Sampel 30 ekor tikus putih dibagi ke dalam 5 kelompok secara random. Masing-masing kelompok terdiri dari 6 ekor tikus putih. Kelompok terdiri dari Kelompok Kontrol Normal (K1), Kelompok Kontrol Negatif dengan Pemberian Pakan Hiperkolesterolemik (K2), Kelompok Perlakuan 1 (K3), Kelompok Perlakuan 2 (K4), dan Kelompok Perlakuan 3 (K5). Tikus pada kelompok K2, K3, K4, dan K5 diberi pakan hiperkolesterolemik (campuran 9 ml kuning telur bebek dan  4,5 ml minyak ayam kemudian ditambahkan air sampai 100 ml) sebanyak 6 ml/hari. Tikus pada kelompok K3, K4, dan K5 diberi seduhan kayu manis dosis 0,5 ml, 1 ml, dan 2 ml/hari. Perlakuan diberikan selama 14 hari. Pada hari ke-15 dilakukan pengambilan darah tikus dan pemeriksaan kadar kolesterol LDL. Data dianalisis menggunakan uji One-Way ANOVA (α = 0,05) dan dilanjutkan dengan uji Post Hoc Multiple Comparisons (LSD) (α = 0,05).
Hasil Penelitian: Pada penelitian ini diperoleh jumlah rerata kadar kolesterol LDL tikus putih kelompok K1 7,33 ± 1,51 mg/dL, K2 9,17 ± 0,98 mg/dL, K3 9,17 ± 2,32 mg/dL, K4 6,17 ± 1,33 mg/dL, dan K5 8,33 ± 1,21 mg/dL. Hasil uji One-Way ANOVA menunjukkan nilai p = 0,010. Hasil uji Post Hoc LSD menunjukkan perbedaan yang bermakna antara K1-K2, K1-K3, K2-K4, K3-K4, dan K4-K5 dengan nilai p < 0,05. Sedangkan untuk pasangan kelompok K1-K4, K1-K5, K2-K3, K2-K5, serta K3-K5 terdapat perbedaan yang tidak bermakna (p > 0,05).
Simpulan: Pemberian seduhan kayu manis dapat menurunkan kadar kolesterol LDL darah tikus putih yang diinduksi pakan hiperkolesterolemik dan dosis seduhan kayu manis yang paling efektif dalam penelitian ini adalah 1 ml/hari.
Kata kunci: seduhan kayu manis, kadar kolesterol LDL, hiperlipidemia
ABSTRACT
Background: Cinnamon contains cinnamic acid, cinnamaldehyde, flavonoids and polyphenols that are known to have potential as antihipercholesterol so it can lower LDL cholesterol levels. This study aimed to determine the effect of cinnamon (Cinnamomum burmanii) infusionagainst blood LDL cholesterol levels in rats (Rattus norvegicus) model of hyperlipidemia.
Methods: This study was laboratory experimental research with the post test only controlled group design. Thirty samples were divided into 5 groups randomly. Each group consisted of 6 rats. The group consists of Normal Control Group (K1), the Negative Control with Hipercholesterolemic Feeding Group (K2), the 1st Treatment Group (K3), the 2nd Treatment Group (K4), and the 3rd Treatment Group (K5). Rats in group K2, K3, K4, and K5 were given 6 ml/day of hipercholesterolemicfeed (mixture of 9 mL of duck yolk egg and 4.5 mL chicken oil then distilled water added until 100 mL). Rats in group K3, K4, and K5 were given cinnamon infusion in dose 0,5 mL, 1 mL, and 2 mL/day. Treatment was given for 14 days. On the 15th day the rats performed blood sampling and LDL cholesterol levels examination. The data were analyzed using One-Way ANOVA test (α = 0.05) and followed by Post Hoc Multiple Comparisons test (LSD) (α = 0.05).
Results: In this research, the average amount of LDL cholesterol in K1 was 7,33 ± 1,51 mg/dL, K2 was 9,17 ± 0,98 mg/dL, K3 was 9,17 ± 2,32 mg/dL, K4 was 6,17 ± 1,33 mg/dL, and K5 was 8,33 ± 1,21 mg/dL. The results of One-Way ANOVA test showed the value of p = 0.010. The Post Hoc LSD test results showed significant difference between the K1-K2, K1-K3, K2-K4, K3-K4 and K4-K5 with the value of p < 0.05. As for the K1-K4, K1-K5, K2-K3, K2-K5 and K3-K5 there are no significant difference (p > 0.05).
Conclusion: Cinnamon infusion can lower blood LDL cholesterol levelsin rats model of hyperlipidemia and the most effective dose of cinnamon infusion in this study was 1 mL/day.
Keywords: Cinnamon infusion, LDL cholesterol levels, hyperlipidemia