ABSTRAK
Latar Belakang
Penyakit Jantung Koroner memiliki prevalensi dan mortalitas tinggi di Indonesia.
Pasien dengan Penyakit Jantung Koroner yang telah mendapat terapi standar secara
maksimal, masih berisiko untuk terjadinya kejadian kardiovaskuler lebih lanjut, hal
ini disebabkan terapi standar gagal dalam menghambat beberapa jalur inflamasi dan
agregasi trombosit yang berimpilikasi pada penyakit tersebut.
Tujuan Penelitian
Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kolkisin
terhadap penurunan kadar HsCRP dan MPV pada pasien Infark Miokard Akut.
Metode Penelitian
Penelitian eksperimental dengan studi pre dan post yang terandomisasi,
sampel 32 orang, dibagi menjadi 2 kelompok. Kelompok kontrol diberikan plasebo
dan perlakuan diberikan kolkisin 0,5 mg peroral selama 5 hari. Analisis statistik
menggunakan uji beda dua rerata menggunakan uji t dependen atau Mann-Whitney
dan analisa dua mean berpasangan menggunakan uji t independen atau Wilcoxon
diolah dengan SPSS 22 for windows.
Hasil Penelitian
Hasil penelitian menunjukkan bahwa dibandingkan plasebo pemberian kolkisin
secara bermakna menurunkan kadar HsCRP (2,30±2,01 vs 4,21±3,93; p = 0,019)
dan menurunkan ukuran MPV (7,14±1,014 vs 7,98±1,08; p = 0,031). Terdapat
penurunan bermakna selisih kadar HsCRP dan ukuran MPV sesudah dan sebelum
perlakuan antara placebo dan kolkisin. Delta HsCRP (-3,82±2,20 vs -0,57±3,12 ;
p = <0,001), delta MPV ( -2,01±1,16 vs -0,64±0,83 ; p=0,001).
Kesimpulan
Pemberian kolkisin dapat menurunkan kadar HsCRP dan menurunkan ukuran MPV
pada pasien Infark Miokard Akut
Kata kunci: Kolkisin, HsCRP, MPV, Infark Miokard Akut
ABSTRACT
Background
Coronary artery disease (CAD) was still highly prevalent. Its mortality was high.
Despite optimal standard therapy, coronary artery disease patients still face the risk
for further cardiovascular events due to inability of standard therapy in blocking
certain inflammatory pathways and thrombocyte aggregation.
Objective
This study aimed to determine the effects of Colchicine on HsCRP and MPV level
in acute myocardial infarction.
Methods
This was a randomized experimental study with pre and post design. A total of 32
patients were included and divided into two groups. Patients were randomized to
receive colchicine 0,5 mg for five days (n=16) or not (control, n=16). Dependent ttest
or Mann-Whitney test were used to compare means between two groups.
Independent t-test or Wilcoxon test were used to compare paired means between
two groups. All statistical analysis was carried out using SPSS version 22 for
windows.
Results
HsCRP level and MPV were significantly lower in colchicine group compare to
placebo (2,30±2,01 vs 4,21±3,93; p = 0,019); (7,14±1,014 vs 7,98±1,08; p = 0,031).
HsCRP level and MPV after treatment were significantly lower compare to baseline
in colchicine group [Delta HsCRP (-3,82±2,20 vs -0,57±3,12 ; p = <0,001), delta
MPV ( -2,01±1,16 vs -0,64±0,83 ; p=0,001)].
Conclusion
This study showed that colchicine decreased HsCRP level and MPV in acute
myocardial infarction patients.
Keywords: colchicine, HsCRP, MPV, acute myocardial infarction.