ABSTRAKLatar belakang : Gagal jantung masih menjadi masalah kesehatan utama di dunia.Penyebab tersering dari gagal jantung adalah gagal jantung iskemik. Penelitianpenelitianobservasional menemukan peranan high sensitive C-Reactive Protein(hsCRP) dan hitung leukosit total pada kondisi penyakit kronik. Peningkatan neutrofilberhubungan secara positif dengan derajat PJK dan gagal jantung, limfositmenunjukkan hal sebaliknya. RNL mudah dihitung pada banyak rumah sakit.Kemampuan latihan merupakan parameter penting yang dapat diterjemahkan dalamaktivitas sehari-hari. Selain itu, kemampuan latihan ini merupakan prediktor morbiditasdan mortalitas pada pasien gagal jantung.Tujuan : Untuk mengetahui hubungan antara RNL dan kapasitas fungsional jantungdan hs-CRP pada pasien gagal jantung iskemik AHA stage C.Metode : Jenis penelitian ini adalah potong lintang analitik (Cross Sectional Analytic) ,sebanyak 35 pasien gagal jantung iskemik AHA stage C pada poliklinik rawat jalanKSM Jantung dan Pembuluh Darah di RSUD Dr. Moewardi Surakarta. Seluruh sampeldilakukan pemeriksaan rasio neutrofil limfosit dan hs-CRP lalu dilakukan uji treadmill.Data kapasitas fungsional jantung (METs) dan hs-CRP diuji beda dengan Mann-Whitney test berdasarkan mean RNL penelitian terdahulu, sehingga terdapat 2 kelompokRNL <2.3 dan kelompok RNL ??2.3. Uji korelasi untuk menilai adakah hubunganantara 2 variabel menggunakan uji Spearman’s. Dianggap bermakna secara statistik bilanilai p < 0.05.Hasil : Nilai uji beda kapasitas fungsional jantung(METs) dan hs-CRP antarakelompok 1 dank 2 masing-masing mendapatkan nilai p <0.001 dan p= 0.001. Analisiskorelasi RNL dengan METs menggunakan uji Spearman’s menunjukkan RNLberkorelasi negatif bermakna dengan METs (r = -0.600 ; p<0.001) dan berkorelasipositif bermakna dengan hsCRP (r = 0.509; p =0.002). Kurva ROC menunjukkan titikpotong RNL 2.28 mempunyai sensitivitas 73.3 % dan spesifisitas 80% ; Area Under theCurve (AUC) 0.71 ; 95% CI 0.519-0.891 ; p =0.040.Kesimpulan : Terdapat hubungan (korelasi negatif kuat) yang bermakna antara RNLdan METs (r =-0.600; p< 0.001). Terdapat hubungan (korelasi positif sedang) yangbermakna antara RNL dan hsCRP (r = 0.509; p = 0.002). RNL ??2.28 dapatmendiagnosis adanya pasien gagal jantung iskemik AHA stage C dengan kapasitasfungsional jantung yang rendah (< 5 METs).Kata kunci : RNL, kapasitas fungsional jantung, hs-CRP.ABSTRACTBackground : Heart failure is still being a main problem of the world. The main causeof heart failure is due to ischemic problem (ischemic heart failure). Observationalresearchs has found the role of high sensitive C-Reactive Protein (hs-CRP) and totalleucocyte count in many chronic disease. The neutrophyl has positive association withthe severity of coronary heart disease dan heart failure, lymphocyte has not. NLR iseasily measurable in many hospital. The ability to exercise is important parameterwhich can measure as a daily activity. Meanwhile, the ability to exercise is a predictorfor morbidity and mortality in heart failure patient.Objective : To analyze the association between Neutrophyl Lymphocyte Ratio (NLR)and Functional Capacity and high sensitive C-Reactive Protein (hs-CRP) in IschemicHeart Failure AHA Stage C patientsMethods : This is an analytic cross sectional study. As many as 35 patient of ischemicheart failure AHA stage C at outpatient clinics in Cardiovascular Department ofDr.Moewardi’s Hospital, Surakarta were selected consecutively. Peripheral venousblood samples to measure the NLR and hs-CRP were drawn before treadmill test in allstudy population. METs and hsCRP compared using Mann-Whitney-test based onpreliminary study so that will be 2 groups, NLR <2.3 and NLR? 2.3. Correlationanalysis was performed using Spearman’s test. P<0.05 was considered as statisticallysignificant.Result : There was significant different in functional capacity and hs-CRP betweengroup NLR <2.3 and NLR? 2.3 (p <0.001 dan p= 0.001, respectively). Correlationanalysis using Spearman’s test showed that NLR had significant negative correlationwith functional capacity (r = -0.600 ; p<0.001) and significant positive correlation withhs-CRP (r = 0.509; p =0.002). The cut-off value of NLR for prediction of poorfunctional capacity (<5 METs) was >2.28 with a sensitivity of 73.3% and a specificityof 80% in the ROC curve analysis (Area Under the Curve (AUC) 0.71 ; 95% CI 0.519-0.891 ; p =0.040)Conclusion : NLR had significant negative correlation with functional capacity andsignificant positive correlation with hs-CRP. The cut-off value of NLR for prediction ofpoor functional capacity (<5 METs) was >2.28 with a sensitivity of 73.3% and aspecificity of 80%Keywords : NLR, functional capacity, hs-CRP.