ABSTRAKLatar Belakang: Pekerja industri kuku palsu berpotensi terpapar bahan kimiayang dapat mengiritasi saluran pernapasan. Iritasi saluran pernapasan dapatmempermudah terjadinya Infeksi Saluran Pernapasan Akut (ISPA). Karakteristikpekerja dan perilaku pekerja mempengaruhi terjadinya ISPA pada pekerja.Penelitian ini bertujuan untuk mengetahui hubungan karakteristik pekerja danperilaku pekerja terpapar bahan kimia dengan gejala ISPA di industri kuku palsuPurbalingga.Metode Penelitian: Penelitian ini merupakan penelitian observasional analitikdengan pendekatan cross sectional. Penelitian ini dilakukan di industri kuku palsuPurbalingga pada bulan November-Desember 2015 dengan sampel sebanyak 80pekerja terdiri dari 48 pekerja bagian injection dan 32 pekerja bagian airbrush.Variabel bebas penelitian ini adalah karakteristik pekerja dan perilaku pekerja.Karakteristik pekerja meliputi jenis kelamin, umur, bagian kerja, masa kerja, danlama bekerja. Perilaku pekerja meliputi perilaku penggunaan Alat Pelindung Diri(APD) berupa masker dan perilaku merokok. Variabel terikat penelitian ini adalahgejala ISPA. Variabel moderator penelitian ini adalah paparan bahan kimia.Pengambilan data dilakukan menggunakan kuesioner. Data yang diperolehdianalisis dengan analisis regresi logistik ganda.Hasil Penelitian: Hasil analisis regresi logistik ganda menunjukkan variabel yangberpengaruh terhadap gejala ISPA adalah lama bekerja (p = 0,000; PR = 13,28)dan umur (p = 0,001; PR = 10,53).Simpulan Penelitian: Lama bekerja dan umur mempengaruhi gejala ISPA padapekerja terpapar bahan kimia di industri kuku palsu Purbalingga. Kekuatanhubungan lama bekerja lebih besar dari umur.Kata Kunci: Karakteristik pekerja, perilaku pekerja, paparan bahan kimia, gejalaISPAABSTRACTBackground: Artifical nails industry workers are potentially exposed tochemicals that can irritate the respiratory tract. Irritation of the respiratory tractmay facilitate the occurrence of Acute Respiratory Infection (ARI). Workercharacteristics and worker behaviors affect the occurrence of ARI. This researchaimed to know the association between characteristics and behaviors of workersthat exposed to chemicals with ARI symptoms in artificial nails industry ofPurbalingga.Methods: This research was an observational analytic with cross-sectionalapproach. The research was held in artificial nails industry of Purbalingga onNovember-December 2015 with 80 samples of workers which consisted of 48workers of injection department and 32 workers of airbrush department.Independent variables of this research were worker characteristics and workerbehaviors. Worker characteristics included gender, age, department of work,period of work, and length of work. Worker behaviors included behavior of theuse of Personal Protective Equipment (PPE) such as masks and smoking behavior.Dependent variable of this research was ARI symptoms. Moderator variable ofthis research was chemicals exposure. Data were collected using questionnaires.Data were analyzed by multiple logistic regression analysis.Results: The results of multiple logistic regression analysis showed that variablesthat influence ARI symptoms were length of work (p = 0.000; PR = 13.28) andage (p = 0.001; PR = 10.53).Conclusions: Length of work and age influenced ARI symptoms of workers thatexposed to chemicals in artificial nails industry of Purbalingga. The strength ofthe relationship of length of work was greater than age.Keywords: Worker characteristics, worker behaviors, chemicals exposure, ARIsymptoms