Penulis Utama | : | Wahyu Mustadi |
NIM / NIP | : | S601102007 |
Pendahuluan: Penyakit paru obstruktif kronik (PPOK) adalah suatu kondisi yang melibatkan beberapa organ dan sistem. Salah satu manifestasi penting dari PPOK
adalah disfungsi otot rangka dan muscle wasting, seiring keparahan penyakit pasien dengan PPOK terjadi kehilangan massa otot , terutama otot paha dan lengan atas. Pasien mengeluh kehilangan daya tahan terhadap latihan, kelelahan dan sesak saat aktivitas hanya dengan tenaga minimal. Carnitine adalah nutrisi yang berperan penting dalam produksi energi dan metabolisme asam lemak. Metode dan Analisis: Penelitian ini adalah uji klinis eksperimental dengan pretest and post-test design yang bertujuan untuk mengetahui pengaruh pemberian L-Carnitine terhadap %VEP1 dan skor CAT. Subjek terdiri dari 30 penderita PPOK stabil yang rawat jalan di RSUD Dr. Moewardi Surakarta bulan mulai Maret-April 2016. Sampel diambil secara purposive sampling. Subjek dibagi dua kelompok yaitu kelompok L-Carnitine (n=15) mendapatkan terapi standar dan tambahan L-Carnitine 1x1000 mg/hari selama 4 minggu dan kelompok kontrol (n=15) hanya mendapat terapi standar PPOK stabil. Nilai
%VEP1 dan skor CAT diukur saat masuk dan pasien kontrol.
Hasil: Terdapat perbedaan bermakna secara statistik (p= 0.020) terhadap nilai
%VEP1 pada kelompok L-Carnitine yang sebelumnya 46.90±22.82 (pretest)
menjadi 58.79±28.88 (posttest).Terdapat perbedaan bermakna secara statistik (p =
0,023) terhadap skor CAT pretest pada kelompok L-Carnitine 16.80+ 6.17 yang menurun menjadi 14.13+13.00 (posttest).
Simpulan: Penambahan L-Carnitine 1x1000 mg/hari selama 4 minggu bermakna secara statistik terhadap kenaikan nilai %VEP1 dan skor CAT pada pasien PPOK stabil.
Introduction: Chronic obstructive pulmonary disease (COPD) is a condition that involves multiple organs and systems. One of the important extrapulmonary manifestations of COPD is skeletal muscle dysfunction and wasting, with increasing severity of disease, patients with COPD lose muscle bulk, especially in
their thighs and upper arms. Over time, these patients lose exercise endurance and complain of fatigue and dyspnoea with only a minimal degree of exertion.Carnitine is a conditionally essential nutrient that plays a vital role in energy production and fatty acid metabolism.
Methode:This research is an experimental study with pretest and post-test design. The aims are to determine the effect of L-Carnitine on CAT score, and %VEP1 of stable COPD patients. Subject of the study consisted of 30 patients with stable of COPD were treated in out patients hospitals Dr. Moewardi Surakarta in march– april 2016. The sample was taken by purposive sampling. Subjects were divided into two groups, the L-Carnitine group (n=15) received standart treatment and L-Carnitine 1x1000 mg/day and the control group (n=15) only received standart treatment. % VEP1 and CAT scores was measured on admission and revisit. Result: There was no statistically significant difference (p=0.761) towards decreased of CAT score between L-Carnitine group (14.13±13.00) and control group (14,93±8.14).There was no statistically significant difference (p=0.061) towards decreased of %VEP1 result between L-Carnitine group (11.89±20.70) and control group (-1.06±7.77).
Conclusion: The addition of L-Carnitine 1x1000 mg/day during 28 days helpful to increase %VEP1results and CAT Score on stable COPD patients..