ABSTRACT Background: More than 40 of all malignancy on woman were gynecologic cancer.the most common cancer is cervical cancer. On advance stage of cervical cancer, theremay be a stres that comes from biologic, psychology and social aspects. The patientsmay face a physical and emotional burden which could activate the mechanism respoof HPA-axis. Repeat activation could impair HPA-axis and circadian rhythm of corti             Psychotherapy, especially logotherapy is found to give benefit on cancer patien 'stherapy by improving their knowledge about their disease and therapy, improving theiremotional adjustment, quality of life, survival ability, satisfaction of therapy, as ell -physical and functional heath adjustment.Methods: This study using experimental double blind non randomized clinicalpost-test group design towards cortisol serum level advance stage cervical cancer. T.-'"subjects of this study using purposive random sampling which consist of 30 patiedevided into 15 patients on control group, and the other 15 were treated group. Co ~group were having standard therapy only while treated group were having a 6 ses iologoteraphy with 45 minutes duration on each session for a week plus standard theAll subjects were met the inclusion and exclusion criteria. The result were anal rzSPSS 19.0 version for windows and using t test.Result: Distribution of mean cortisol level were lower in the serum of patientsgroup (3,99±5,22 ng/ml), compared with the control group (20,28±7,44 ng rz,Analysis of cortisol level variables using the Kolmogorov-Smirnov test in both cnY ••• ....."c,:,showed the results are normally distributed with p=0,069 (p>0,05), for the tre ~group and p=0,805 (P>0,05) for the control group. The results of t-test hosignificant difference with p=O,OOO «0,05).Conclusion: There is an effectiivity of logotherapy towardscortisol serum Iadvanced stage cervical cancer. Keywords: Cervical cancer, Logotherapy, Cortisol serum level