Abstrak

Background. Accurate and early detection of bacteriemia holds important role for management and prognostic of neonatal sepsis, however the limitation of spesific sepsis marker remain obstacles. Neutrophil to lymphocyte count ratio (NLCR) in adult population shows sensitive parameter to predict infection and has economic and available superiority. The role of NLCR in the neonate population has not been widely studied.

Objectives. To analyze NLCR compare to CRP as neonatal sepsis predictor.
    
Methods. This study take analytic observatinal with diagnostic test approach to subject with sepsis risk factor and neonatal sepsis at dr. Moewardi hospital from April until May 2017. Characteristics data as gestational age, gender, birth weight, IT ratio, leucocyte count, neutrophil and lymphocyte count, NLCR, CRP and blood culture. Data presented descriptively and statistical analysis was performed.

Results. No significant correlation between subject’s characteristics and neonatal sepsis. NLCR with cutoff point for 2.215 has sensitivity, specificity, positive and negative predictive value for 87.5%, 75%, 70% and 90%, respectively. CRP with cutoff point for 0.25 has sensitivity, specificity, positive and negative predictive value for 83.3%, 55.6%, 55.6% and 83.3% respectively. While IT-rasio has sensitivity, specificity, positive and negative predictive value for 29.2%, 91.7%, 70% and 66%, respectively.

Conclusion. NLCR has a better satisfactory predictive value for neonatal sepsis than a CRP that widely available and as economic predictor alternative with cutoff point for 2,215.

Keywords : NLCR, CRP, Predictor, Neonatal Sepsis