Abstrak

World Health Organization recorded that one third of the world's population has LTBI, and HIV infection is a major risk factor of LTBI. The gold standard of LTBI diagnosis remains unclear. Both of TST and IGRAs have weaknesses, especially in HIV infected patient. The purpose of this study was to analyze TST and T-SPOT.TB on detection LTBI in HIV infected patient.
Diagnostic test research with cross sectional study design. The target population is HIV infected patient who qualify inclusion and exclusion criterias in outpatient of VCT policlinics in Dr.Moewardi Hospital on January 2017.
Out of the total 88 research subjects HIV infected patient obtained 26 (29.54%) cases of LTBI. The degree of compliance between the TST and T-SPOT.TB with ? = 0.442 (95% CI: 0.212 to 0.672, p=0,000) represents fair to good agreement. The sensitivity and specificity of the TST are 14.3% and 78.3%, and T-SPOT.TB are 28.6% and 81.7%. There is no correlation between the amount of CD4 + cells with TST (r=-0,037, p = 0.733) and T-SPOT.TB (r=-0,048, p = 0.658). There is no correlation between the amount of neutrophil cells with TST (r=-0,040, p = 0.714) and T-SPOT.TB (r= 0,004, p = 0.972).  
The degree of compliance is unfavorable between TST and T-SPOT.TB, therefore diagnostic test can not replace each other to detection LTBI in HIV infected patient. The sensitivity and specificity of the T-SPOT.TB is higher than the TST, but they are inferior for detection LTBI in HIV infected patient. There is no correlation between the amount of CD4 + cells and neutrophil cells with TST and T-SPOT.TB to detection LTBI in HIV infected patient.

Keywords : Latent TB infection, HIV infection, TST, T-SPOT.TB, CD4+ cell, neutrophil cell