Background: Colorectal cancer is a malignancy of the colon and / or rectum. Vitamin D has a role as an inhibitor of tumor progression, namely through the process of influencing cellular differentiation and proliferation. VDR (Vitamin D receptor) affects cell differentiation by increasing the expression of brush boundary enzymes and improving morphological microvilli. The purpose of this study was to see the relationship between 25(OH)D levels and the prevalence of colorectal cancer in dr. Moewardi Hospital.

Method: This study is an analytic observational quantitative study with a cross-sectional study approach with patients with indications of colorectal cancer who have never been diagnosed or previously diagnosed, consisting of 46 patients who were then taken 25(OH)D samples at dr. Moewardi Surakarta and subsequent diagnostic measures from the results of histopathology were assessed. The parameters assessed were 25(OH)D level and a diagnosis of colorectal ca. Statistical analysis of 25(OH)D levels and colorectal diagnosis using the Chi Square test.

Result: Chi Square test results showed a significant relationship between 25(OH)D levels and the prevalence of colorectal cancer with a significant value of p = 0.004 (p <0>

Conclusion: There is a significant relationship between 25(OH)D deficiency and the occurrence of colorectal cancer.