Background: Pain is a common complaint that causes decreased work productivity and a cause of disability. Biomedical interventions failed to inhibit the increase in chronic low back pain (CLBP) treatment costs. The pain perception of CLBP patients is influenced by emotional psychological and cognitive factors that require biopsychosocial intervention. This study aims to summarize existing literature data regarding the effectiveness of biopsychosocial interventions with Cognitive Behavioral Therapy (CBT) and Exercise Therapy Program (ETP) in CLBP.
Subjects and Method: Systematic review research and meta-analysis of Randomized Control Trial studies on electronic databases of Pubmed, Google scholar, Willey Online Library, Research Gate, Science Direct. Data analysis used the Revman 5.3 program with Cohen's d effect size.
Results: 7 articles included in this study. The results of the analysis of the study on the effectiveness of biopsychosocial interventions for CBT and ETP in reducing the intensity of CLBP pain were very large with the effect size (d = -1.31; CI; -2.39 to -0.23; p <0 xss=removed>Conclusion: biopsychosocial interventions with CBT and ETP are effective in reducing the pain and disability index of CLBP. The effectiveness of biopsychosocial interventions with CBT and ETP is due to the patient's efficacy in completing the rehabilitation program.

Key Words: biopysichosocial, CBT, ETP, CLBP