Diabetes mellitus is a disease associated with insulin hormone disorders characterized by increased levels of glucose in the blood. Diabetes mellitus causes an increase in free radicals that can cause damage to body cells, including liver cells. Catfish oil (Pangasius djambal) and ethanol extract of bitter herbs (Andrographis paniculata (Burm.f.) Ness.) are thought to be used to reduce liver damage. Liver damage is characterized by increased levels of SGPT. SGPT is a specific enzyme that is used as an indicator of liver damage. The purpose of this study was to examine the effect of giving a combination of catfish oil and ethanol extract of bitter herbs on the SGPT levels of the model streptozotocin-induced diabetic rats. Were wistar rats divided into several groups including normal controls given corn oil without diabetes induction, negative group induced diabetes, metformin group given 120 mg/KgBW of metformin, group I given catfish oil 1000 mg/kgBW, group II given a combination of oil catfish 1000 mg/kgBW and sambiloto extract 200 mg/kgBW, and group III was given catfish oil 1000 mg/kgBW and sambiloto extract 400 mg/kgBW orally. All groups other than the normal group were induced by intraperitoneal streptozotocin and after being declared diabetes were given treatment for 28 days. On the 14th and 28th days, blood was drawn through the eye vein and the serum was separated for testing for SGPT levels. The data obtained were statistically analyzed using the One Way ANOVA method. The results showed that the combination of catfish oil and ethanol extract of sambiloto in the treatment group was able to significantly inhibit the increase in SGPT levels of diabetic rats induced by streptozotocin significantly compared to the negative control group (p<0>