ABSTRAK Asam folat merupakan vitamin esensial bagi metabolisme manusia, namun memiliki permasalahan stabilitas dan rentan terhadap paparan oksigen, cahaya, serta panas. Penelitian ini bertujuan untuk mengevaluasi stabilitas dan sifat fisikokimia asam folat dengan kokristal asam folat-asam traneksamat. Pembuatan kokristal dilakukan menggunakan metode solvent evaporation dengan menggunakan pelarut asam asetat glasial. Uji stabilitas prediktif dipercepat dilakukan pada kondisi stres dengan suhu 50 °C dan kelembapan relatif 90% selama waktu penyimpanan 30 hari. Karakterisasi stabilitas dievaluasi menggunakan Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), dan spektrofotometri UV-Vis. Sifat fisikokimia sediaan dievaluasi melalui Particle Size Analyzer (PSA) dengan metode Dynamic Light Scattering (DLS), pengukuran zeta potensial, pengamatan morfologi menggunakan Scanning Electron Microscopy(SEM), serta penentuan porositas dengan metode perhitungan Girolami. Hasil penelitian menunjukkan bahwa kokristal asam folat-asam traneksamat memiliki keunggulan stabilitas jangka pendek yang lebih baik dibandingkan dengan asam folat murni yang ditunjukkan oleh parameter DSC yang lebih stabil, serta tidak adanya perubahan signifikan pada difraktogram XRD hingga masa penyimpanan hari ke-10. Berdasarkan kinetika spektrofotometri UV-Vis, kokristal memiliki konstanta degradasi (k) yang hampir sama (0,02611) dengan asam folat murni (0,0257). Pada evaluasi sifat fisikokimia, citra SEM dan data PSA menunjukkan bahwa asam folat murni mengalami aglomerasi dan pelelehan parsial akibat paparan panas dan kelembapan, sedangkan kokristal asam folat-asam traneksamat dapat mempertahankan struktur berpori dan granularnya. Kokristal memiliki persentase porositas sebesar 70,4%, yang menyeimbangkan dan memperbaiki tingginya porositas asam folat murni dalam memperbaiki profil tabletabilitas serta sifat alirnya. Secara keseluruhan, pembentukan kokristal dengan koformer asam traneksamat terbukti efektif untuk meningkatkan profil stabilitas fisik jangka pendek, stabilitas koloid, serta menutupi kekurangan sifat mekanis asam folat.ABSTRACT Folic acid is an essential vitamin for human metabolism, but it has stability issues and is susceptible to exposure to oxygen, light, and heat. This study aims to evaluate the stability and physicochemical properties of folic acid compared to folic acid-tranexamic acid cocrystals. Cocrystal preparation was carried out using the solvent evaporation method using glacial acetic acid as a solvent. Accelerated predictive stability testing was conducted under stress conditions at 50°C and 90% relative humidity for 30 days of storage. Stability characterization was evaluated using Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and UV-Vis spectrophotometry. The physicochemical properties of the preparation were evaluated using a Particle Size Analyzer (PSA) using the Dynamic Light Scattering (DLS) method, zeta potential measurement, morphological observation using Scanning Electron Microscopy (SEM), and porosity determination using the Girolami calculation method. The results showed that the folic acid-tranexamic acid cocrystal had a better short-term stability advantage compared to pure folic acid as indicated by the more stable DSC parameters, as well as the absence of significant changes in the XRD diffractogram until the 10th day of storage. Based on UV-Vis spectrophotometric kinetics, the cocrystal had similar degradation constant (k) (0,02611) compared to pure folic acid (0,0257). In the evaluation of physicochemical properties, SEM images and PSA data showed that pure folic acid experienced agglomeration and partial melting due to exposure to heat and humidity, while the folic acid-tranexamic acid cocrystal could maintain its porous and granular structure. The cocrystal had a porosity percentage of 70.4%, which balanced and improved the high porosity of pure folic acid in improving its tabletability profile and flow properties. Overall, the formation of cocrystals with tranexamic acid coformers proved effective in improving the short-term physical stability and colloidal stability profiles, as well as covering the deficiencies in the mechanical properties of folic acid.